Side-by-side specifications of the Synology RS2421RP+ and RS2818RP+, from official datasheets. Differences are highlighted.
| RS2421RP+ | RS2818RP+ | |
| CPU | AMD Ryzen V1500B | Intel Atom C3538 |
| Cores / threads | 4 cores / 8 threads | 4 cores / 4 threads |
| RAM (base) | 4 GB DDR4 ECC UDIMM | 4 GB DDR4 non-ECC UDIMM |
| RAM (max) | 32 GB | 64 GB |
| Drive bays | 12 | 16 |
| Expandable to | 24 total with 1x RX1217/RX1217RP | 12 |
| M.2 slots | 0 internal; optional PCIe adapter | 0 (via optional adapter card) |
| Network | 4 x 1GbE RJ-45 | 4 x 1GbE RJ-45 |
| 10GbE | optional | optional |
| Max raw capacity | 108 TB per volume; 24 bays with expansion | 336 TB |
| Hot-swap | yes | yes |
| Form factor | Rackmount 2U | 3U |
| Released | 2021 | 2018 |
| Power consumption | — | 138.1 W / 66.7 W |
| DSM at launch | — | — |