Side-by-side specifications of the Synology RS2421RP+ and RS2423RP+, from official datasheets. Differences are highlighted.
| RS2421RP+ | RS2423RP+ | |
| CPU | AMD Ryzen V1500B | AMD Ryzen V1780B |
| Cores / threads | 4 cores / 8 threads | 4 cores / 8 threads |
| RAM (base) | 4 GB DDR4 ECC UDIMM | 8 GB DDR4 ECC UDIMM |
| RAM (max) | 32 GB | 32 GB |
| Drive bays | 12 | 12 |
| Expandable to | 24 total with 1x RX1217/RX1217RP | 24 |
| M.2 slots | 0 internal; optional PCIe adapter | 0 |
| Network | 4 x 1GbE RJ-45 | 2×1GbE RJ-45 + 1×10GbE RJ-45 |
| 10GbE | optional | yes |
| Max raw capacity | 108 TB per volume; 24 bays with expansion | 216 TB |
| Hot-swap | yes | yes |
| Form factor | Rackmount 2U | 2U |
| Released | 2021 | 2023 |
| Power consumption | — | 114.86 W / 42.33 W |
| DSM at launch | — | — |