Side-by-side specifications of the Synology RS2416RP+ and RS2421RP+, from official datasheets. Differences are highlighted.
| RS2416RP+ | RS2421RP+ | |
| CPU | Intel Atom C2538 2.4GHz | AMD Ryzen V1500B |
| Cores / threads | 4 cores / 4 threads | 4 cores / 8 threads |
| RAM (base) | 2GB DDR3 | 4 GB DDR4 ECC UDIMM |
| RAM (max) | 6GB | 32 GB |
| Drive bays | 12 | 12 |
| Expandable to | 12 | 24 total with 1x RX1217/RX1217RP |
| M.2 slots | 0 | 0 internal; optional PCIe adapter |
| Network | 4x 1GbE RJ-45 | 4 x 1GbE RJ-45 |
| 10GbE | no | optional |
| Max raw capacity | 168TB with RX1214/RX1214RP | 108 TB per volume; 24 bays with expansion |
| Hot-swap | yes | yes |
| Form factor | 2U rackmount | Rackmount 2U |
| Released | 2016 | 2021 |
| Power consumption | — | — |
| DSM at launch | — | — |