Side-by-side specifications of the Synology RS1221RP+ and RS1619xs+, from official datasheets. Differences are highlighted.
| RS1221RP+ | RS1619xs+ | |
| CPU | AMD Ryzen V1500B | Intel Xeon D-1527 |
| Cores / threads | 4 cores / 8 threads | 4 cores / 8 threads |
| RAM (base) | 4 GB DDR4 ECC SODIMM | 8 GB DDR4 ECC UDIMM |
| RAM (max) | 32 GB | 64 GB |
| Drive bays | 8 | 4 |
| Expandable to | 12 with RX418 | 16 total with RX1217/RX1217RP |
| M.2 slots | 0; optional adapter card | 2 M.2 2280 NVMe/SATA |
| Network | 4× 1GbE RJ-45 | 4 × 1GbE RJ-45 |
| 10GbE | optional | optional |
| Max raw capacity | 108 TB single volume | 192 TB |
| Hot-swap | yes | yes |
| Form factor | 2U rackmount | 1U rackmount |
| Released | 2020 | 2019 |
| Power consumption | 61.94 W / 29.98 W | 68.68 W / 34.78 W |
| DSM at launch | — | — |
Choose the RS1221RP+ for redundant power and higher storage capacity: it has an AMD Ryzen V1500B, 4 GB ECC RAM expandable to 32 GB, eight bays plus expansion support, optional 10GbE, and no built-in M.2 slots. Choose the RS1619xs+ for performance: it has a quad-core Intel Xeon D-1521, 8 GB ECC RAM expandable to 32 GB, four bays plus expansion, built-in dual M.2 NVMe slots, and optional 10GbE.