Side-by-side specifications of the Synology RS1221+ and RS1221RP+, from official datasheets. Differences are highlighted.
| RS1221+ | RS1221RP+ | |
| CPU | AMD Ryzen V1500B | AMD Ryzen V1500B |
| Cores / threads | 4/8 | 4/8 |
| RAM (base) | 4 GB | 4 GB |
| RAM (max) | 32 GB | 32 GB |
| Drive bays | 8 | 8 |
| Expandable to | 12 | 12 |
| M.2 slots | 2 | 0 |
| Network | 4x 1GbE RJ-45 | 4x 1GbE |
| 10GbE | optional | optional |
| Max raw capacity | 108 TB | 108 TB |
| Hot-swap | yes | yes |
| Form factor | 2U | 2U |
| Released | 2021 | 2025 |