Side-by-side specifications of the Synology HD6500 and SA6400, from official datasheets. Differences are highlighted.
| HD6500 | SA6400 | |
| CPU | 2x Intel Xeon Silver 4210R | AMD EPYC 7272 |
| Cores / threads | 20 cores / 40 threads | 12/24 |
| RAM (base) | 64 GB | 32 GB |
| RAM (max) | 512 GB | 1024 GB |
| Drive bays | 60 | 12 |
| Expandable to | 300 | 108 |
| M.2 slots | 0 | 0 |
| Network | 2x 1GbE + 2x 10GbE + 1x OOB | 4x 1GbE, 2x 10GbE |
| 10GbE | yes | yes |
| Max raw capacity | 1 PB | 1.944 PB |
| Hot-swap | yes | yes |
| Form factor | 4U rackmount | 2U rackmount |
| Released | 2025 | 2025 |