Side-by-side specifications of the Synology DS1621xs+ and SA6400, from official datasheets. Differences are highlighted.
| DS1621xs+ | SA6400 | |
| CPU | Intel Xeon D-1527 2.2/2.7 GHz | AMD EPYC 7272 |
| Cores / threads | 4 cores / 8 threads | 12 cores / 24 threads |
| RAM (base) | 8 GB DDR4 ECC SODIMM | 32 GB DDR4 ECC RDIMM |
| RAM (max) | 32 GB | 1024 GB |
| Drive bays | 6 | 12 |
| Expandable to | 16 total with 2× DX517 | 108 |
| M.2 slots | 2× M.2 2280 NVMe | — |
| Network | 2× 1GbE RJ-45, 1× 10GbE RJ-45 | 4×1GbE RJ-45, 2×10GbE RJ-45, 1×management LAN |
| 10GbE | yes | yes |
| Max raw capacity | 96 TB internal; 256 TB with 2× DX517 | 1.944 PB |
| Hot-swap | yes | yes |
| Form factor | Tower | 2U rackmount |
| Released | 2020 | 2025 |
| Power consumption | — | 180.5 W / 88.56 W |
| DSM at launch | — | — |