Side-by-side specifications of the Synology DS1621xs+ and DS3622xs+, from official datasheets. Differences are highlighted.
| DS1621xs+ | DS3622xs+ | |
| CPU | Intel Xeon D-1527 2.2/2.7 GHz | Intel Xeon D-1531 |
| Cores / threads | 4 cores / 8 threads | 6 cores / 12 threads |
| RAM (base) | 8 GB DDR4 ECC SODIMM | 16 GB DDR4 ECC SODIMM |
| RAM (max) | 32 GB | 48 GB |
| Drive bays | 6 | 12 |
| Expandable to | 16 total with 2× DX517 | 36 (with 2 DX1222) |
| M.2 slots | 2× M.2 2280 NVMe | 0 (requires adapter card) |
| Network | 2× 1GbE RJ-45, 1× 10GbE RJ-45 | 2 x 1GbE, 1 x 10GbE RJ-45 |
| 10GbE | yes | yes |
| Max raw capacity | 96 TB internal; 256 TB with 2× DX517 | 200 TB single volume |
| Hot-swap | yes | yes |
| Form factor | Tower | tower |
| Released | 2020 | 2021 |
| Power consumption | — | 94.42 W / 54.33 W |
| DSM at launch | — | 7.0 |