Side-by-side specifications of the Synology DS1621xs+ and DS2422+, from official datasheets. Differences are highlighted.
| DS1621xs+ | DS2422+ | |
| CPU | Intel Xeon D-1527 2.2/2.7 GHz | AMD Ryzen V1500B 2.2 GHz |
| Cores / threads | 4 cores / 8 threads | 4 cores / 8 threads |
| RAM (base) | 8 GB DDR4 ECC SODIMM | 4 GB DDR4 ECC SODIMM |
| RAM (max) | 32 GB | 32 GB |
| Drive bays | 6 | 12 |
| Expandable to | 16 total with 2× DX517 | 24 total with DX1222 |
| M.2 slots | 2× M.2 2280 NVMe | 0 built-in; optional adapter card |
| Network | 2× 1GbE RJ-45, 1× 10GbE RJ-45 | 4× 1GbE RJ-45 |
| 10GbE | yes | optional |
| Max raw capacity | 96 TB internal; 256 TB with 2× DX517 | 108 TB per volume |
| Hot-swap | yes | yes |
| Form factor | Tower | desktop |
| Released | 2020 | 2021 |
| Power consumption | — | 73.11 W / 32.12 W |
| DSM at launch | — | — |